Chemotherapy, Epidemiology, Diagnosis, Management, and Treatment of Breast Cancer
Review
DOI:
https://doi.org/10.33005/jdiversemedres.v2i10.78Keywords:
Asthma, biomarkers, endotype, immunologyAbstract
Asthma is a chronic inflammatory disease of the airways triggered by an immune response involving Th22 cells and group 3 innate lymphoid cells (ILC2). The disease is divided into two main endotypes: type 2-high, characterized by eosinophilic inflammation and a good response to corticosteroids; and type 2-low, which is associated with neutrophilic inflammation and a response to non-type 2 cytokines. The aim of this literature review is to examine the immunology of asthma, its pathogenesis, biomarkers, genetics, epigenetics, and management strategies.Literature was sourced from several databases such as Google Scholar and PubMed using relevant keywords. The review findings indicate that type 2-high asthma responds well to corticosteroid therapy, whereas type 2-low asthma requires treatment targeting non-type 2 cytokines. Biomarker-based approaches are crucial in asthma management, with studies showing that plant-based diets and vitamin D intake can help control asthma. A deeper understanding of asthma endotypes and associated biomarkers is essential for developing more personalized and effective treatment strategies.
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