Iron's Contribution to Children's Cognitive Development throughout the First 1000 Days of Life : A Literature Review
A Literature Review
DOI:
https://doi.org/10.33005/jdiversemedres.v3i1.284Keywords:
iron, first 1000 days, cognitive development, iron supplementation, childAbstract
Background: Iron is an essential micronutrient that plays a critical role in brain development through processes such as myelination, neurotransmitter synthesis, energy metabolism, and synaptogenesis. Iron deficiency during the first 1000 days of life can disrupt neural network formation and lead to long-term cognitive impairments that are often irreversible.
Objective: This literature review aims to analyze the contribution of iron during the first 1000 days of life to children’s cognitive development and to emphasize the importance of nutritional interventions starting from pregnancy.
Methods: This literature review was conducted using primary research articles published in English or Indonesian between 2020 and 2025. Relevant studies were identified through systematic searches in PubMed, ScienceDirect, Google Scholar, and ResearchGate, employing the PICO framework and appropriate keywords.
Results: Adequate iron status from pregnancy through early childhood is crucial for optimal cognitive development. Sufficient iron supports myelination, neurotransmitter synthesis, and the development of memory, language, and learning abilities. Conversely, iron deficiency during the first 1000 days of life is associated with reduced cognitive function, developmental delays, and an increased risk of long-term neurocognitive disorders.
Conclusion: Optimal iron intake during the first 1000 days of life is essential to support maximal brain development, prevent long-term cognitive impairments, and enhance children’s future intellectual potential.
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Kementerian Kesehatan Republik Indonesia. Zat besi dan peranannya dalam tumbuh kembang anak. LMS Kemenkes; 2025 [Internet]. Tersedia dari: https://lms.kemkes.go.id/courses/aa32926b-d0b2-44e4-9227-1c8aefb8e6eb
Fesmia HL, Putri LL, Suryantini NKM, Nurhidayati N. Nutrisi pada 1000 hari pertama kehidupan (HPK) sebagai dasar perkembangan kognitif: sebuah kajian pustaka. Jurnal Kedokteran Unram. 2023;12(3):987. doi:10.29303/jku.v12i3.987
McCann S, Perapoch Amadó M, Moore SE. The role of iron in brain development: a systematic review. Nutrients. 2020;12(7):2001. doi:10.3390/nu12072001. Tersedia dari: https://pmc.ncbi.nlm.nih.gov/articles/PMC7400887/
Likhar A, Patil MS. Importance of maternal nutrition in the first 1,000 days of life and its effects on child development: a narrative review. Cureus. 2022;14(10):e30083. doi:10.7759/cureus.30083. Tersedia di: https://pubmed.ncbi.nlm.nih.gov/36381799/
Cusick SE, Georgieff MK. The role of nutrition in brain development: the golden opportunity of the first 1000 days. J Pediatr. 2016;175:16–21. doi:10.1016/j.jpeds.2016.05.013. Tersedia di: https://pubmed.ncbi.nlm.nih.gov/27266965/
Theola J, Andriastuti M. Neurodevelopmental impairments as long-term effects of iron deficiency in early childhood: a systematic review. Balkan Med J. 2025;42(1):108–120. doi:10.4274/balkanmedj.2689. Tersedia di: https://balkanmedicaljournal.org/text.php?id=2689&lang=tr
Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007;28(4 Suppl):S560-71. doi:10.1177/15648265070284S409. Tersedia di: https://pubmed.ncbi.nlm.nih.gov/18297894/
Generasi Maju. Dampak kekurangan zat besi terhadap kognitif anak. 2024 [Internet]. Tersedia dari: https://www.generasimaju.co.id/artikel/1-tahun/nutrisi/dampak-kekurangan-zat-besi-terhadap-kognitif-anak
Wessling-Resnick M. Iron homeostasis and the inflammatory response. Annu Rev Nutr. 2010;30:105-22. doi:10.1146/annurev-nutr-082409-085400. Tersedia di: https://pmc.ncbi.nlm.nih.gov/articles/PMC3108097/
Fretham SJ, Carlson ES, Georgieff MK. The role of iron in learning and memory. Adv Nutr. 2011;2(2):112-21. doi:10.3945/an.110.000190. Tersedia di: https://pubmed.ncbi.nlm.nih.gov/22332040/
Geng F, Mai X, Zhan J, Xu L, Zhao Z, Georgieff M, Shao J, Lozoff B. Impact of fetal-neonatal iron deficiency on recognition memory at 2 months of age. J Pediatr. 2015 Dec;167(6):1226-32. doi:10.1016/j.jpeds.2015.08.035. Tersedia di: https://pubmed.ncbi.nlm.nih.gov/26382625/
Lozoff B, Beard J, Connor J, Felt B, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006 May;64(5 Pt 2):S34–43; discussion S72–91. doi:10.1301/nr.2006.may.s34-s43. Tersedia di: https://pubmed.ncbi.nlm.nih.gov/16770951/
German K, et al. Enteral Iron Supplementation in Infants Born Extremely Preterm and Its Positive Correlation with Neurodevelopment (PENUT Trial). J Pediatr. 2021;238:102-109.e2. doi:10.1016/j.jpeds.2021.06.075. Tersedia dari: https://pmc.ncbi.nlm.nih.gov/articles/PMC8629150/
McCann S, et al. Iron status in early infancy is associated with trajectories of cognitive development up to pre-school age in rural Gambia. Proc Nutr Soc. 2023;82(OCE1):E29. doi:10.1017/S0029665123000376. Tersedia dari: https://pubmed.ncbi.nlm.nih.gov/37910494/
Iglesias-Vázquez L, et al. Importance of Maternal Iron Status on the Improvement of Cognitive Function in Children After Prenatal Iron Supplementation. Nutrients. 2023;15(4):1023. doi:10.3390/nu15041023. Tersedia dari: https://pubmed.ncbi.nlm.nih.gov/36906495/
Luciano A, et al. Neurological development and iron supplementation in healthy late-preterm neonates: a randomized double-blind controlled trial. BMC Pediatr. 2021;21(1):315. doi:10.1186/s12887-021-02787-w. Tersedia dari: https://pubmed.ncbi.nlm.nih.gov/34291331/
Luo R, et al. Chronic Iron Deficiency and Cognitive Function in Early Childhood. Pediatrics. 2022;149(6):e2021055129. doi:10.1542/peds.2021-055129. Tersedia dari: https://pubmed.ncbi.nlm.nih.gov/36412051/
Ferdi F, Bardosono S, Medise BE. Iron status and developmental delay among children aged 24-36 months. Paediatr Indones. 2022;62(1):47-54. doi:10.14238/pi62.1.2022.47-54. Tersedia dari: https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2701
Sitorus SM, Salsabila A. Impact of Iron Deficiency on Cognition in School Age Children. J Nutr Sci. 2023;8:e45. doi:10.1017/jns.2023.35. Tersedia dari: https://www.researchgate.net/publication/372967450_Impact_of_Iron_Deficiency_on_Cognition_in_School_Age_Children
Qin Y, et al. Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study. Nutr J. 2025;24(1):15. doi:10.1186/s12937-025-01197-3. Tersedia dari: https://nutritionj.biomedcentral.com/articles/10.1186/s12937-025-01197-3
Bah A, et al. Early Iron Supplementation of Exclusively Breastfed African Infants: A Randomized Double-Blind Efficacy Trial. medRxiv [Preprint]. 2023 Jan 12:2023.01.12.22284059. doi:10.1101/2023.01.12.22284059. Tersedia dari: https://www.medrxiv.org/content/10.1101/2023.01.12.22284059v1.full-text
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