Medical Education in the Age of AI: Shaping Technologically Literate yet Humanistic Doctors

Rika Yuliwulandari, Ilham Kurniawan, Laurentius Johan Ardian — Wed, 29 Jul 2026 00:00:00 +0000

Preamble

A fundamental question facing medical educators today is this: How do we prepare future doctors for a world where artificial intelligence is reshaping every aspect of clinical practice, without losing the humanistic core that defines the art of medicine? This is no longer a theoretical debate it is an urgent pedagogical imperative.

As Editor-in-Chief and Deputy Editor-in-Chief of Medicosphere, we believe this question demands our immediate attention. AI is rapidly transforming healthcare reshaping clinical decision-making, diagnostic imaging, and patient care. Deep learning algorithms have demonstrated remarkable performance in tasks such as image classification, leading to improved diagnostic accuracy. Yet, paradoxically, at the very moment when technology offers unprecedented capabilities, the need for distinctly human qualities in medicine empathy, compassion, ethical reasoning, and clinical wisdom has never been greater. The challenge before us is clear: we must train doctors who are not only technologically literate but also deeply humanistic. This is not an either‑or proposition. It is both.

Exploration of Alpha-Curcumene and Curdione from Turmeric (Curcuma longa L.) to MurB Enzyme as Antibacterial through Molecular Docking Analysis

Argha Rodzikin Adilaga, Annisa Mutiara Mecca , Ilham Kurniawan — Wed, 29 Jul 2026 00:00:00 +0000

Antimicrobial resistance (AMR) has emerged as a critical global health threat, necessitating the discovery of antibacterial agents with novel mechanisms of action. MurB, an essential enzyme in bacterial cell wall biosynthesis, represents an attractive target due to its absence in humans. This study aimed to evaluate the in silico antibacterial potential of α-curcumene and curdione, two bioactive constituents of turmeric essential oil, as inhibitors of the MurB enzyme. The three-dimensional structure of MurB was retrieved from the Protein Data Bank. The chemical structures of α-curcumene and curdione were obtained from the PubChem database. Molecular docking was performed using AutoDock Vina, with naphthyl tetronic acid (co-crystallized ligand) as a positive control. Binding affinities and interaction profiles were analyzed using PyMOL and Discovery Studio Visualizer. The native ligand exhibited a binding energy of -8.6 kcal/mol. Curdione demonstrated a binding energy of -6.7 kcal/mol, while α-curcumene showed -5.9 kcal/mol. Both compounds docked within the catalytic pocket, interacting with key residues Glu325, Ser229, and Arg159. Curdione exhibited superior binding affinity compared to α-curcumene. Although both compounds showed weaker binding affinity than the native ligand, their ability to occupy the MurB active site suggests they are promising lead scaffolds for antibacterial drug development. Further in vitro and in vivo studies are warranted to validate their biological activity.

Journal of Diverse Medical Research : Medicosphere

Medical Education in the Age of AI: Shaping Technologically Literate yet Humanistic Doctors

Exploration of Alpha-Curcumene and Curdione from Turmeric (Curcuma longa L.) to MurB Enzyme as Antibacterial through Molecular Docking Analysis