Association Between Long-Term Progesteron Exposure and Intracranial Meningioma: A Case Report in a 44-Year-Old Woman

Andini Nur Ramadhani — 2026-06-15

Background: Meningioma is a common benign intracranial tumor originating from arachnoid cap cells and accounts for approximately one-third of all primary brain tumors. Its higher incidence in women suggests hormonal involvement, particularly from progesterone and progestogen exposure. Prolonged use of hormonal contraceptives, such as depo medroxyprogesterone acetate (DMPA), has been associated with the development and progression of meningioma. Objective: To describe the clinical presentation, neuroimaging findings, management, and possible association between long-term progesterone exposure and intracranial meningioma in a middle-aged woman.

Methods: We report the case of a 44-year-old woman with a history of long-term DMPA use who presented with progressive neurological symptoms. Clinical evaluation, neuroimaging studies, surgical treatment, and histopathological examination were performed and reviewed.

Results: The patient presented with recurrent severe headache, blurred vision, and a progressively enlarging right-sided scalp mass. She had received DMPA injections for more than 15 years. Contrast-enhanced brain CT demonstrated a well-defined right frontotemporal extra-axial mass consistent with meningioma. The patient subsequently underwent craniotomy and complete tumor excision. Histopathological examination confirmed a WHO Grade I meningioma with mixed meningothelial and angiomatous patterns.

Conclusion: This case highlights a potential association between prolonged DMPA exposure and intracranial meningioma. Early recognition of neurological symptoms, timely neuroimaging evaluation, and appropriate surgical management are essential to optimize outcomes. Discontinuation of hormonal exposure should also be considered in patients with hormone-sensitive meningiomas.

Integrating One Health into Food Systems: A Literature Review on Health Risks and Sustainability

Leonardo Tedjaprasadja — 2026-04-30

Background: The food system is a complex network that shapes health outcomes across human, animal, and environmental domains. Increasing globalization, agricultural intensification, and environmental changes have amplified risks such as zoonotic diseases and antimicrobial resistance (AMR). The One Health approach provides an integrated framework to address these interconnected challenges. This study aimed to examine the role of One Health in food systems through a literature review of studies published between 2014 and 2025.

Methods: Articles were retrieved from PubMed, Scopus, and Google Scholar using relevant keywords. Selected studies were analyzed using a thematic approach focusing on human, animal, and environmental health perspectives.

Results: The findings indicate that food systems serve as important pathways for zoonotic disease transmission and the spread of AMR, particularly through intensive livestock production and inappropriate antibiotic use. In addition, food production contributes to environmental degradation, including pollution and greenhouse gas emissions, which further affect health outcomes.

Conclusion: Despite increasing recognition of the One Health approach, its implementation remains limited, especially in developing countries. Strengthening interdisciplinary collaboration and integrated policies is essential to improve food system safety, public health, and environmental sustainability.

Journal of Diverse Medical Research : Medicosphere

Association Between Long-Term Progesteron Exposure and Intracranial Meningioma: A Case Report in a 44-Year-Old Woman

Integrating One Health into Food Systems: A Literature Review on Health Risks and Sustainability