Journal of Diverse Medical Research : Medicosphere

Medical Education in the Age of AI: Shaping Technologically Literate yet Humanistic Doctors

Rika Yuliwulandari — 2026-08-17

Preamble

A fundamental question facing medical educators today is this: How do we prepare future doctors for a world where artificial intelligence is reshaping every aspect of clinical practice, without losing the humanistic core that defines the art of medicine? This is no longer a theoretical debate it is an urgent pedagogical imperative.

As Editor-in-Chief and Deputy Editor-in-Chief of Medicosphere, we believe this question demands our immediate attention. AI is rapidly transforming healthcare reshaping clinical decision-making, diagnostic imaging, and patient care. Deep learning algorithms have demonstrated remarkable performance in tasks such as image classification, leading to improved diagnostic accuracy. Yet, paradoxically, at the very moment when technology offers unprecedented capabilities, the need for distinctly human qualities in medicine empathy, compassion, ethical reasoning, and clinical wisdom has never been greater. The challenge before us is clear: we must train doctors who are not only technologically literate but also deeply humanistic. This is not an either‑or proposition. It is both.

Exploration of Alpha-Curcumene and Curdione from Turmeric (Curcuma longa L.) to MurB Enzyme as Antibacterial through Molecular Docking Analysis

Argha Rodzikin Adilaga — 2026-08-17

Antimicrobial resistance (AMR) has emerged as a critical global health threat, necessitating the discovery of antibacterial agents with novel mechanisms of action. MurB, an essential enzyme in bacterial cell wall biosynthesis, represents an attractive target due to its absence in humans. This study aimed to evaluate the in silico antibacterial potential of α-curcumene and curdione, two bioactive constituents of turmeric essential oil, as inhibitors of the MurB enzyme. The three-dimensional structure of MurB was retrieved from the Protein Data Bank. The chemical structures of α-curcumene and curdione were obtained from the PubChem database. Molecular docking was performed using AutoDock Vina, with naphthyl tetronic acid (co-crystallized ligand) as a positive control. Binding affinities and interaction profiles were analyzed using PyMOL and Discovery Studio Visualizer. The native ligand exhibited a binding energy of -8.6 kcal/mol. Curdione demonstrated a binding energy of -6.7 kcal/mol, while α-curcumene showed -5.9 kcal/mol. Both compounds docked within the catalytic pocket, interacting with key residues Glu325, Ser229, and Arg159. Curdione exhibited superior binding affinity compared to α-curcumene. Although both compounds showed weaker binding affinity than the native ligand, their ability to occupy the MurB active site suggests they are promising lead scaffolds for antibacterial drug development. Further in vitro and in vivo studies are warranted to validate their biological activity.

Complete Resection of A Giant Convexity Meningioma Involving The Middle Cerebral Artery: A Case Report and Surgical Considerations

M. Irfan Rahmatullah — 2026-08-17

Meningioma is the most common primary intracranial tumor in adults, accounting for approximately 37.6% of all primary central nervous system neoplasms. Although convexity meningiomas are generally surgically accessible, large tumors with neurovascular involvement present significant operative challenges, especially when acute neurological deterioration necessitates emergent intervention. A 46-year-old female presented with decreased consciousness (GCS E2V3M4) and progressive hemiparesis. Preoperative CT revealed a large temporoparietal extra-axial mass with significant mass effect and middle cerebral artery (MCA) involvement. Emergent craniotomy and stepwise debulking were performed utilizing gravity-assisted retraction, central dural incision, pial plane preservation, early arterial feeder coagulation, and systematic hemostasis. The philosophy of prioritizing patient safety over gross total resection guided the strategy. Postoperatively, the patient regained full consciousness (GCS E4V5M6) with marked motor improvement. Emerging evidence supports subtotal resection with adjuvant stereotactic radiosurgery for residual tumors. Emergent surgical debulking of large convexity meningiomas with neurovascular involvement is feasible and effective when guided by stepwise resection, pial plane preservation, and patient safety. Adjuvant radiosurgery should be considered for any residual tumor on follow-up imaging.

Biopigments from Monascus sp. as Potential Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α) Modulators: A Computational Approach

Dyahati Wahyurini — 2026-08-17

Monascus sp. produces biopigments (ankaflavin, monascin, and rubropunctatin) that have various biological activities, including a role in lipid metabolism through interaction with peroxisome proliferator-activated receptor alpha (PPAR-α). It plays an important role in regulating lipid metabolism and is a therapeutic target. Fenofibrate is one of the antihyperlipidemic drugs that targets PPAR-α. Therefore, this study aimed to evaluate the interaction of ankaflavin, monascin, and rubropunctatin with PPAR-α. The biopigments were analyzed using SwissADME and molecular docking with PPAR-α (PDB ID: 5HYK). The results showed that ankaflavin, monascin, and rubropunctatin complied with Lipinski’s Rule. Molecular docking revealed that all biopigments analyzed had good interactions with PPARα, with binding affinity values of ankaflavin -10.03 kcal/mol, monascin -10.38 kcal/mol, and rubropunctatin -10.62 kcal/mol. Rubropunctatin had the most negative binding affinity and the lowest predicted Ki (16.45 µM) among the tested biopigments and was most similar to the positive control, fenofibrate (−10.78 kcal/mol and 12.59 µM). In conclusion, these findings suggest that biopigments from Monascus sp. are potential candidates for PPAR-α modulators, particularly rubropunctatin. Further in vivo and in vitro investigations are necessary to validate these findings.

Association between Poverty Rate and Stunting Prevalence in Central Java

Qonita Abdillah Rosyida — 2026-08-17

Stunting refers to impaired growth and development in children resulting from chronic nutritional deficiencies, especially during the critical period of the first 1,000 days of life. This study aimed to generate more comprehensive empirical evidence on the association between poverty prevalence and stunting rates among districts and municipalities in Central Java. This study using a quantitative approach, this study analyzed secondary data through a correlational framework. The dataset covered all 36 administrative regions in Central Java Province, where district-level poverty rates and stunting prevalence served as the primary variables of analysis. The relationship between poverty and stunting identified should be interpreted as an association rather than a direct causal link. The findings suggest that poverty contributes to variations in child nutritional status, although it does not fully account for the complexity of underlying determinants. Therefore, poverty should be regarded as an important, yet not exclusive, factor. This study provides evidence of a significant positive association between district-level poverty rates and stunting prevalence in Central Java. The moderate correlation indicates that regions with higher poverty rates are more likely to have elevated stunting prevalence.